Wednesday , January 20 2021

a promising new track to better understand its development



Researchers have focused their efforts on the role of blood flow in the development of Alzheimer's disease affecting nearly 900,000 people in France. Maxisciences explains

It is the most common neurodegenerative disease of the nervous system, but this disease remains incurable today, and many researchers see it as Alzheimer's. Today, researchers can be on the right track by taking an unprecedented approach.

A new approach to Alzheimer's research

One of the causes of Alzheimer's disease is the accumulation of senile plaques, also called amyloid plaques, between neurons. They are named officials of researchers from change of mental functions sick and many are the researchers who fight to limit their development. But it cerebral blood flow could also have its role to play.

Scientists already know about the existence of a reduced blood flow the brain in humans with Alzheimer's disease. The latter occurs before the development of amyloid plaques. Researchers from the Department of Fluid Mechanics (CNRS-Paul Sabatier University-INP) and Cornell University gathered in the project Brain Microflow. The researchers involved in the project, led by Nozomi Nishimura and Chris Schaffer, analyzed the blood flow in the brain of a model of animal testing (in mice).

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Neutrophiles responsible?

But who is responsible for lowering cerebral blood flow in patients? The guilty here are them: neutrophil. These are White blood cells which clings to the walls of the capillaries cerebral cortex and join in block blood flow. The researchers didn't stop there: they discovered it the injection of specific antibodies neutrophils allowed unclog the capillaries and remove white blood cell residues. Everyone with an advantage not to neglect: a increased blood flow in the cerebral cortex.

"We did not destroy the neutrophils, but we prevented them from clinging to the walls. This allowed the mice to recover their capacity quicklyexplains Sylvie Lorthois, from the Fluid Mechanics Institute of Toulouse in 20 minutes. The latter modeled this discovery human brain. this progress could be significant for research on Alzheimer's diseasein fact, the reduction of cerebral blood flow is one of the first symptoms of this neurodegenerative disease.


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