Saturday , January 16 2021

Appetite Suppressors for Humans: Scientists may have found the lethal anti-mosquito weapon

STUDY – Cut the appetite of the mosquito so that they are no longer their prey. This is the idea of ​​researchers at Rockefeller University, New York (USA), to complete the bites and especially with the deadly diseases they transmit.

Sprays against stings … For centuries, mosquitoes and humans have fought each other in a relentless war. But this time they may have found death weapons. Researchers at Rockefeller University in New York have found something to reduce their appetite: a banal appetite for men.

For their research, published on February 7 in the journal Cellthey used these substances to manipulate the satiety hormones of female mosquitoes of the Aedes aegypti species. It is responsible for the spread of many diseases such as yellow fever, dengue, chikungunya and zika virus.

Satiated mosquitoes

For this study, the researchers started from the observation that when the mosquitoes had fed blood, their interest in humans would go to bed for several days. "This is the perfect example of a Thanksgiving dinner," says Rocfeller University Researcher Laura Duvall, one of the researchers involved in the study.

They then focused their research on the neuropeptides Y (NPY), these receptors, which interfere with the regulation of vital needs, both in humans and mosquitoes. By analyzing one by one the ninety-nine NPY insects, they succeeded in identifying the one responsible for regulating the appetite, NPYLR7.

To respond, American scientists have relied on molecules used by the pharmaceutical industry to regulate appetite. Six connections were eventually chosen for their ability to act on mosquitoes without doing the same on humans. They were diluted in saline for administration to the insects. As a result, the mosquitoes rinse their sweet sin, a nylon stocking worn for several hours and soaked in body odor. Dito to the mouse under general anesthesia, which was offered to them on a plateau.

We were impressed and surprised that the drugs designed to act on human appetites worked perfectly to cut the hunger of the mosquito.Leslie Vausshall, author of the study

"We were impressed and surprised that the drugs designed to act on human appetites worked perfectly to cut the hunger of the mosquito," says Rockefeller University Leslie Vosshall, study author. According to the researcher, this discovery will reduce the risk of "mosquito populations developing resistance, as is the case with insecticides," as it does not kill women.

Other research must now be carried out in real conditions, in nature. The molecules could be transmitted through the seed of genetically modified mosquitoes, or by bait mimicking human odor which has the advantage of attracting only mosquitoes and other insects that suck human blood. If this succeeds, this discovery can benefit the fight against other diseases such as Lyme or malaria, ticks and anopheles mosquitoes are also susceptible to appetite suppression, the US University says.

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