Thursday , December 3 2020

Identify compounds in coffee that can inhibit prostate cancer



Coffee is a complex mixture of compounds that have been shown to affect human health both positively and negatively. For the first time, Japanese researchers have identified coffee compounds that can inhibit the growth of prostate cancer.

This conclusion, which is part of a pilot study rperformed in cells of cancer resistant to substances in cell cultures and in a mouse model will be presented at congress The European Association for Urology in Barcelona (USA), which is celebrated until this Tuesday after its publication in the magazine Prostate.

The researchers first tested Six compounds naturally found in coffee, on cell proliferation & # 39; in vitro & # 39; human prostate cancer –it is in a petri dish and not in humans.

Then they found it cells treated with kahweol acetate and cafestol grew slower what do you check then tested these compounds on prostate cancer cells that had been transplanted into mice (16 mice). As controls they used mice, 4 were further treated with kahweol acetate, another 4 with cafestol, and the remaining mice were treated with a combination of kahweol acetate and cafestol.

There are growing signs that drinking certain types of coffee is associated with a reduction in the incidence of some cancers, including cancer prostate. Now, Japanese researchers have studied the effects of two compounds found in coffee, kahweol acetate and cafestol, in prostate cancer cells and in animals where they could inhibit the growth of cells resistant to common anticancer drugs such as cabazitaxel.

Study leader, Dr. Hiroaki Iwamoto from the Institute of Integrated Cancer Therapy and Urology, Higher School of Medical Sciences of Kanazawa, Japan, first author of the study, has pointed out that "It's important to keep these results in perspective." "We found that kahweol acetate and cafestol inhibit the growth of mouse cancer cells, but the combination seemed synergistic, leading to significantly slower tumor growth than in untreated mice. After 11 days, the untreated tumors had grown around 3 and a half times the original volume (342%), whereas the tumors in the mice treated with both compounds grew about half and a half (167%) times the original size ".

This is a pilot study, so this work shows that the use of these compounds is scientifically viable, but requires more research; It does not mean that the results can still be applied to humans. We also found reduced growth in transplanted tumor cells, rather than in native tumor cells.

"What it shows is that these compounds seem to have an effect on prostate cancer cells – drug-resistant cells under the right circumstances and they also need more research. We are currently considering how to test these findings in a larger sample and then in humans, "he adds.

the Kahweol acetate and cafestol are hydrocarbons, found naturally in arabica coffee. "These are promising results, but they should not make people change their coffee consumption. Coffee can have positive and negative effects (for example, it can increase hypertension) so we need to find out more about the mechanisms behind these findings before we can think of clinical applications, "added Professor Atsushi Mizokami of the Department of Health. Integrated Cancer Therapy and Urology, Graduate School of Medical Sciences of Kanazawa, Japan.

He added, however, that "if we can confirm these results, we can get candidates to treat prostate cancer resistant to drugs."


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