Sunday , November 29 2020

Mexico-American research identifies the gene in the Mexican population



A genetic study by a Mexican-American scientific consortium has identified a gene present at mestizos and natives in our country that can develop diabetes MODY (Maturity-onset diabetes of the young), which manifests itself at age 45 in people who are usually not overweight and require the use of insulin soon.

In the first part of the study, samples of DNA from more than eight thousand Mexicans were taken, half of which were based in Mexico City and the other in Los Angeles, California; In the second phase, just over four thousand citizens participated, with a 75 percent relationship in the capital of the country and the rest in the Californian city.

This major study is sponsored by the SIGMA Consortium (Slim Initiative in Genomic Medicine of the Americas), which integrates researchers from Broad Institute (from Harvard University and the Massachusetts Institute of Technology, USA), from the National Institute of Nutrition Salvador Zubirán and from the Institute of Biomedical Research of UNAM, of Mexico.

"It took a long time to gather the samples, and based on genetic information plus clinical data, look for the variant among millions of data generated. When we had them, the whole DNA was sequenced and it took us a year to address the information and conclude what the needle would be in the haystack, "says Mexican scientist Karol Estrada, a researcher at the analytical and translational genetic unit of Massachusetts General Hospital. and in Broad Institute in Boston.


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