Researchers from CNRS, the University of Caen-Normandy, the University of Paris-Est Créteil and the OTR3 company are working on a new way of helping victims of stroke, a treatment that would regain the sensory and engine lost functions due to stroke.
In France, approximately 150,000 people suffer from stroke each year. Stroke is the main cause of acquired disability in adults, and the second leading cause of death in France.
Most of these types are due to occlusion of a cerebral artery of blood clot. The only way to prevent neurons die because they are deprived of oxygen is to eliminate this blood clot. This surgery is only possible during the first few hours after stroke, which can only treat a minority of patients.
Against this background, a group led by CNRS researcher Myriam Bernaudin decided to explore a new road and was interested in the cell environment, also called extracellular matrix. The matrix serves as support for the cells. When a stroke occurs, it interferes with the matrix, which enhances neuronal support.
The research group has injected into a rat an agent similar to the components that structure the cell matrix. This drug injected after a stroke proved to be effective, as it was allowed to protect and reconstruct the matrix affected. This means has also helped to promote the development of new neurons and to promote the recovery of sensory and motor functions.
Currently, only tested on rats, this promising track should be subject to pilot studies by the end of 2019.