Wednesday , April 21 2021

Immunosuppression prevents early delivery



Early childbirth is the leading cause of death and disability in the United States, which costs a thousand dollars and grief each year.

Now, a report from researchers at the University of Connecticut in reproductive science shows a potential treatment that can stop many premature born and born back to normal.

Hartford Hospital Obstetrician Christopher Nolde and Immunologist Anthony Villa are fascinated with the role of the immune system in early birth.

Usually, most pregnancies last for about 40 weeks, so a child born before the 37th week may be too small to regulate body temperature and can not breathe. In some cases, he may have brain bleeding or any other organic problems, such as delayed growth and problems with knowledge and perception.

In this country alone, about 337,000 children were born before their natural birth in 2016. However, in other mammals, early delivery was very rare and usually occurs during infection or inflammation.

Researchers have known cytokines – small proteins that warn the body for infection and cause inflammation – in fetal fluid in many early children. This makes them wonder if the fetus is completely different from her mother. It will be attacked by the mother's immune system, but there is something to prevent it during pregnancy. What happens if this protection stopped some women?

"There are many antiinflammatory mechanisms that prevent immune rejection of the fetus, so we thought that severe inflammation could break the endurance barrier and start giving birth and premature birth," said Villa.

So Nold and Villa took cells from the female genital tract and fetal fluid surrounding embryos in the uterus and introduced them to parts of the bacteria in the laboratory. The result was what they expected because the cells produced a lot of cytokines as if shouting: "There is gas!"

However, cytokines were not initially the type of inflammation that the researchers expected and instead saw a large proportion of the factors that stimulate grazing and granulation colonies (GM-CSF). GM-CSF is a type of cytokine that causes cell growth to rapidly become large follicle cells.

Peat concentrations in pregnant women tend to rise immediately before birth, but it is unclear whether this is directly related to birth or to the adversion of another procedure.

The discovery of Nold and Villa as cytokine (GM-CSF) released in response to perceived bacterial infection is strange due to the presence of GM-CSF.

Treatment of pregnant mice with this drug Early birth was significantly reduced in mice exposed to parts of the dangerous bacteria, so preventing premature birth makes it easy to change the rules of the game.

Nold and Villa presented a temporary patent on technology, but researchers must first know if cytokine (GM-CSF) is causing women's premature birth, so Nold collects samples from some women early during pregnancy to see if there is anything. detected early to determine the cause of premature birth.

Nolde and Villa want to test these samples of cytokine (GM-CSF) and see if their high levels early during pregnancy are indicative of premature termination of pregnancy.

"We hope to do more studies on the immune system in rats and hopefully we will look at human studies," said Nold. "Hartford Hospital has already given them a small contribution and is now looking for more funding to continue its research.


  • Translation: Kenan Meri
  • Check: RAND EAAM
  • Editing: زيد أبو الرب


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