Wednesday , October 27 2021

Soon a test to detect the risk of sudden death in infants?



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A team of doctors from the Strasbourg Hospital Center has just published a study on vagal hyperactivity. Taking into account her observations, she hopes to generalize a blood test to detect the risk of sudden death in infants.

Strasbourg doctors, who have just published a study on vagal hyperactivity, hope to eventually generalize a blood test to detect newborns at risk of sudden death, a syndrome that affects hundreds of babies each year in France.

These Strasbourg CHRU doctors have highlighted the link between vagal hyperactivity and repetitive disorder, in a study published in mid-July by Public Library of Science, which could pave the way for the display of a party "Not insignificant" babies at risk of sudden death.

Between 300 and 400 cases of sudden death each year

A sudden infant death is a source of anxiety among young parents and childcare professionals "300 to 400 deaths per year"according to cardiologist Angelo Livolsi, who has been in charge since 2017 with pediatrician resuscitator Charlie De Melo from a "Young research protocol", where the CHUs in Reims, Besançon and Nancy also attend.

"This is the first study to provide biological evidence, both in adults and in children with repeated discomfort, that there is some vagal hyperactivity and that we can offer them treatments"says Dr. The Melo.

After examining rabbits, this study was based on samples taken from adults and children who were prone to syncope compared to those from healthy subjects. It shows the association between overexpression of muscarinic receptors, an enzyme believed to regulate these receptors, and syncope. "There are receptors located at the heart level, and sometimes the mechanism that counteracts the stress system (acceleration of the heartbeat, increase in tension) is excessive, the heart slows down too much and the brain is less perfused.", sums up Dr. The Melo.

An adult loses consciousness for a few seconds, will sweat, but will recover spontaneously "In some newborns who have pathological muscarinic overexpression, this can lead to complete cardiac arrest"he adds. "Until now we were a little lost in the face of these discomfort because we were only on clinical signs, but there by taking a blood test we can measure the importance of overexpression and how the enzyme works"concludes Dr. Livolsi.

When abnormal levels of receptors and enzyme are identified, the patient can be treated with "An anti-muscarinic synthesis"already prescribed in Strasbourg by Dr. Livolsi, following families with a history of vagal hyperactivity.

Screening on the third day after birth

Strasbourg doctors continue their research by taking samples, at parents' agreement, of infants under one year old admitted for severe discomfort to establish reference values ​​for newborn and premature infants.

Ultimately, they would like to offer the blood test they have developed "On a large scale at the same time as other newborn screenings", performed at the age of 3 days.

"The idea would be to detect these patients before they have severe discomfort and treat them during their first year of life, that is, the period of maximum risk."says Dr. The Melo.

We're talking about the infant's unexpected death "To designate a sudden death for a child under 2 years, often less than 6 months, and sudden death Infant " when there is no study to identify the cause of death.

Smoking and overheated room are risk factors

The number of cases fell by 75% in France after 1994, when the health authorities recommended sleeping babies on their backs and not on the stomach or side, but "Stagnant since the 2000s"explains Dr. Karine Levieux, Scientific Coordinator of the Observatory for the Infant's Unexpected Deaths based in Nantes.

"Sleeping children on the stomach was the first risk factor", she says, while emphasizing that the infant's unexpected death is "Probably of multifactorial origin".

If low birth weight and premature babies are especially exposed, she cites among the factors in "External stress" increase the risk of exposure to passive smoking, a soft mattress or an overheated room.

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Soon a test to detect the risk of sudden death in infants?Ouest-France.fr

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