Lock George Kruis will miss England's remaining autumn test against Japan and Australia with a calf injury.
The British and Irish lions, 28, were replaced by Charlie Ewels late in Saturday's 16-15 defeat of New Zealand.
England also misses Joe Launchbury in second line, meets Japan on Saturday and Australia on November 24 in Twickenham.
Ewels, Maro Itoje, Elliott Stooke and Courtney Lawes are the locks in the 30-man panel.
More to follow.