Thursday , February 25 2021

Antibiotics are the cause of 33,000 deaths in Europe

The study has used monitoring data from 30 European countries (EU and EEA) by 2015, and researchers have looked at 16 different combinations of bacteria and antibiotic resistance. This includes bacteria that are considered to be common causes of infection in the hospital and are immediately resistant to groups of antibiotics that are considered critical to human medicine.

"The largest disease burden is calculated for countries in southern Europe, while Norway and other Nordic countries are the best, victory researches Petter Elstrøm at Norway's public health institute who has participated in the study.

Disease that prevents their resistant bacteria has increased the significance levels in the last eight years and the largest contributes to a number of infections caused by resistant Klebsiella pneumoniae and Escherichia coli. 75 percent of the disease burden can be associated with hospital infections and 39 percent obesity gram-negative bacteria that are resistant to last line antibiotics such as carbapenem and colistin. This means that there are few or no effective antibiotics left that can be used against infections caused by these bacteria.

It was estimated that almost 1 900 people in Norway quarter to one year get an infection of the resistant bacteria included in the study. This causes about 69 additional deaths as a result of the bacteria being resistant to antibiotics. Elstrøm points out that the calculations in the study are good with the good surveillance data we have in Norway.

A resistant bacterium with good monitoring data in Norway is Meticillin-resistant Staphylococcus aureus (MRSA). The study estimates that 17 per cent of patients receive blood infections with MRSA every quarter of this year. In the Norwegian Infectious Disease System (MSIS), by 2015, 11 people with such MRSA infections have been registered. Because the cause of infections is not always identified, I would like to say that the results in the study correspond to the surveillance data we have in Norway, both for MRSA infections and for other infections of resistant bacteria reported to MSIS, "says Elstrøm.

For the first time, the disease burden is measured by antibiotic resistant bacteria in the form of DALY (day-adjusted life-years). DALY is a target for the disease burden that expresses cough for many years lost due to reduced health, functional ability and premature death. DALY is often used to compare the burden of different disease states or to compare the burden between countries and different populations. DALY can and can estimate the costs of the disease burden. Such cost analyzes are made in a standardized way to compare costs associated with different states.

The study estimates that the disease burden of the resistant bacteria amounts to approximately 1 700 DALY in Norway. Converting to crowns and ear causes the disease burden of their resistant bacteria an annual cost to society of approximately 2 billion Norwegian kronor, "Elstrøm points out.

The Organization for Economic Cooperation and Development (OECD) has used the results of this study to make more accurate estimates of the economic burden associated with resistant bacteria. This is published in a separate OECD report, which is in line with Superbug Tide, which is public on November 7 this year.

Although the burden of disease is significant and increasing in Europe, it is still possible to make softness to reverse the trend.

The most important options we can do in Norway and globally are to reduce the consumption of antibiotics. In addition, we must ensure that good contamination measures prevent the spread of resistant bacteria and contribute to the research and development of new types of antibiotics, "says Elstrøm.

Allotable deaths and invalidity-adjusted life years caused by infections with antibiotic resistant bacteria in the EU and European Economic Area 2015: a population level modeling (The Lancet)

Healthcare related infections, antibiotic treatment (NOIS), antibiotic resistance (MSIS) and World Hand Hygiene Day. Annual Report 2017. (National Institute of Public Health)

European Antibiotics Awareness Day (ECDC)

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