It is the view of former United midfielder and BT Sport pundit Owen Hargreaves, who thinks Nemanja Matic and Paul Pogba could face the Italian champions if they were to play.
Jose Mourinho's men dropped home 1-0 home to Old Lady at Old Trafford two weeks ago and left those who struggled to qualify from their group.
While still in second place in the squad, defeat to Juve would see that United's match in Valencia had extra significance.
Mourinho still looks at Pogba and Matic as his first choice in the midfield and they are likely to get zero tonight, but both have had their problems sometimes this season.
Pogba returns to face on his previous side in Turin after replacing Bianconeri for the Red Devils in a £ 89m deal two years ago.
But Hargreaves has major doubts about Pogba and Matic against Juve and their lack of mobility in the midfield.
And he believes Ander Herrera is the perfect foyer for United during the match.
"I like Herrera and I'm not sure why he has not played as much considering how important he seemed two years ago," Hargreaves told BT Sport.
"I do not think they will win midfield in Turin"
"As much as Matic is, he seems to have lost some confidence and he does not seem to be the absolute best.
"Like Pogba, Matic is about 6ft 3in and if they have control over the ball that is good but out of possession it's hard for them against the little fast guys.
"The [Paulo] Deep in this world for example, perhaps Herrera would be a good partner because he is a little more mobile and active in his possession. "
Hargreaves also insists that United must be harder in the middle of the park.
He added: "I do not think they will win the midfielder battle in Turin, I think it's unrealistic to think that given the shape they are in.
"But what you have to do is make it difficult for those who [Miralem] Pjanic and [Rodrigo] Bentancur who just crossed Old Trafford. You can not allow these guys on the ball to get their heads up.
"If you're sitting outside of Juventus, they'll hit you but if you try to hurry on them and put a little on them, I do not care how good they are, they will not like it."
With Valencia home to young boys earlier this Wednesday, it is important to get away with some kind of result against Juve for the red devils.